2,457 research outputs found
Biodiversity and climate change: Risks to dwarf succulents in Southern Africa.
The aim of this study was to explore the effects of anthropogenic climate change on the dwarf succulent genus Conophytum (Aizoaceae) within areas recognised for their floral biodiversity, namely the Succulent Karoo, Fynbos, Desert and Nama Karoo biomes of South Africa and Namibia. Niche-based modelling was used to identify the key climatic and geological variables influencing the distribution of members of the genus Conophytum. The distribution of the genus is primarily controlled by a small number of environmental variables, notably winter and summer rainfall levels, together with geology. Assuming a zero-dispersal model, the predicted effect of both the A1B and A2 climatic emission scenarios was a severe contraction in the area satisfying the bioclimatic envelope for the genus coupled with significant range dislocation. Reductions of >90% in suitable habitat for 10 of the 16 taxonomic Sections that comprise the genus and represent >80% of taxa under the A2 scenario are predicted. Under A1B the projected effects are ameliorated, but reductions of >50% of habitat can be seen in a majority of Sections. Significant projected reductions in the habitable bioclimatic envelope are very likely to increase risk of extinction of ~80% of taxa even under a partly mitigated emissions scenario
Recombinant factorVIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A
This work was supported
by funding from Biogen, including funding for the
editorial and writing support in the the development of
this paper
Dating and relationship violence victimization and perpetration among 11-16 year olds in Wales: a cross-sectional analysis of the School Health Research Network (SHRN) survey
This is the final version. Available on open access from OUP via the DOI in this recordBACKGROUND: This study examines the prevalence of dating and relationship violence (DRV) victimization, perpetration and joint victimization and perpetration, and associations between DRV and socio-demographic characteristics. METHODS: Cross-sectional self-report data from 74 908 students aged 11-16 from 193 schools across Wales were collected and analysed using generalized estimating equations to examine prevalence and predictors of emotional and physical DRV victimization, perpetration and joint victimization and perpetration. RESULTS: More girls reported emotional victimization (28%) and perpetration (18%) than boys (20% and 16%, respectively). More girls (8%) than boys (7%) reported physical perpetration. However, boys (17%) reported more physical victimization than girls (12%). Age-related trajectories of DRV victimization and perpetration were stronger in girls than in boys. Students from single or step parent homes, those in care, and certain ethnic minority groups had increased odds of DRV. No association was found between socioeconomic status and DRV. CONCLUSIONS: Age-related trajectories and the lack of social patterning by socioeconomic status point to the value of early, universal interventions, while some evidence of ethnic patterning and family structure-related risk factors suggest areas for further research and targeted interventions. DRV continues to be a major public health problem for which little UK-specific intervention evidence exists.British Heart FoundationCancer Research UKEconomic and Social Research Council (ESRC)Medical Research Council (MRC)Welsh GovernmentWellcome Trus
A massive reservoir of low-excitation molecular gas at high redshift
Molecular hydrogen is an important component of galaxies because it fuels
star formation and accretion onto AGN, the two processes that generate the
large infrared luminosities of gas-rich galaxies. Observations of spectral-line
emission from the tracer molecule CO are used to probe the properties of this
gas. But the lines that have been studied in the local Universe, mostly the
lower rotational transitions of J = 1-0 and J = 2-1, have hitherto been
unobservable in high-redshift galaxies. Instead, higher transitions have been
used, although the densities and temperatures required to excite these higher
transitions may not be reached by much of the gas. As a result, past
observations may have underestimated the total amount of molecular gas by a
substantial amount. Here we report the discovery of large amounts of
low-excitation molecular gas around the infrared-luminous quasar, APM
08279+5255 at z = 3.91, using the two lowest excitation lines of 12CO (J = 1-0
and J = 2-1). The maps confirm the presence of hot and dense gas near the
nucleus, and reveal an extended reservoir of molecular gas with low excitation
that is 10 to 100 times more massive than the gas traced by higher-excitation
observations. This raises the possibility that significant amounts of
low-excitation molecular gas may lurk in the environments of high-redshift (z >
3) galaxies.Comment: To appear as a Letter to Nature, 4th January 200
Biomolecular imaging and electronic damage using X-ray free-electron lasers
Proposals to determine biomolecular structures from diffraction experiments
using femtosecond X-ray free-electron laser (XFEL) pulses involve a conflict
between the incident brightness required to achieve diffraction-limited atomic
resolution and the electronic and structural damage induced by the
illumination. Here we show that previous estimates of the conditions under
which biomolecular structures may be obtained in this manner are unduly
restrictive, because they are based on a coherent diffraction model that is not
appropriate to the proposed interaction conditions. A more detailed imaging
model derived from optical coherence theory and quantum electrodynamics is
shown to be far more tolerant of electronic damage. The nuclear density is
employed as the principal descriptor of molecular structure. The foundations of
the approach may also be used to characterize electrodynamical processes by
performing scattering experiments on complex molecules of known structure.Comment: 16 pages, 2 figure
Recommended from our members
Risk measures for direct real estate investments with non-normal or unknown return distributions
The volatility of returns is probably the most widely used risk measure for real estate. This is rather surprising since a number of studies have cast doubts on the view that volatility can capture the manifold risks attached to properties and corresponds to the risk attitude of investors. A central issue in this discussion is the statistical properties of real estate returnsâin contrast to neoclassical capital market theory they are mostly non-normal and often unknown, which render many statistical measures useless. Based on a literature review and an analysis of data from Germany we provide evidence that volatility alone is inappropriate for measuring the risk of direct real estate.
We use a unique data sample by IPD, which includes the total returns of 939 properties across different usage types (56% office, 20% retail, 8% others and 16% residential properties) from 1996 to 2009, the German IPD Index, and the German Property Index. The analysis of the distributional characteristics shows that German real estate returns in this period were not normally distributed and that a logistic distribution would have been a better fit. This is in line with most of the current literature on this subject and leads to the question which indicators are more appropriate to measure real estate risks. We suggest that a combination of quantitative and qualitative risk measures more adequately captures real estate risks and conforms better with investor attitudes to risk. Furthermore, we present criteria for the purpose of risk classification
The braincase and jaws of a Devonian 'acanthodian' and modern gnathostome origins.
Modern gnathostomes (jawed vertebrates) emerged in the early Palaeozoic era, but this event remains unclear owing to a scant early fossil record. The exclusively Palaeozoic acanthodians are possibly the earliest gnathostome group and exhibit a mosaic of shark- and bony fish-like characters that has long given them prominence in discussions of early gnathostome evolution. Their relationships with modern gnathostomes have remained mysterious, partly because their un-mineralized endoskeletons rarely fossilized. Here I present the first-known braincase of an Early Devonian (approximately 418-412 Myr bp) acanthodian, Ptomacanthus anglicus, and re-evaluate the interrelationships of basal gnathostomes. Acanthodian braincases have previously been represented by a single genus, Acanthodes, which occurs more than 100 million years later in the fossil record. The braincase of Ptomacanthus differs radically from the osteichthyan-like braincase of Acanthodes in exhibiting several plesiomorphic features shared with placoderms and some early chondrichthyans. Most striking is its extremely short sphenoid region and its jaw suspension, which displays features intermediate between some Palaeozoic chondrichthyans and osteichthyans. Phylogenetic analysis resolves Ptomacanthus as either the most basal chondrichthyan or as the sister group of all living gnathostomes. These new data alter earlier conceptions of basal gnathostome phylogeny and thus help to provide a more detailed picture of the acquisition of early gnathostome characters
Assessing Internet addiction using the parsimonious Internet addiction components model - a preliminary study [forthcoming]
Internet usage has grown exponentially over the last decade. Research indicates that excessive Internet use can lead to symptoms associated with addiction. To date, assessment of potential Internet addiction has varied regarding populations studied and instruments used, making reliable prevalence estimations difficult. To overcome the present problems a preliminary study was conducted testing a parsimonious Internet addiction components model based on Griffithsâ addiction components (2005), including salience, mood modification, tolerance, withdrawal, conflict, and relapse. Two validated measures of Internet addiction were used (Compulsive Internet Use Scale [CIUS], Meerkerk et al., 2009, and Assessment for Internet and Computer Game Addiction Scale [AICA-S], Beutel et al., 2010) in two independent samples (ns = 3,105 and 2,257). The fit of the model was analysed using Confirmatory Factor Analysis. Results indicate that the Internet addiction components model fits the data in both samples well. The two sample/two instrument approach provides converging evidence concerning the degree to which the components model can organize the self-reported behavioural components of Internet addiction. Recommendations for future research include a more detailed assessment of tolerance as addiction component
The Discovery of Two New Satellites of Pluto
Pluto's first known moon, Charon, was discovered in 1978 (Christy 1978) and
has a diameter about half that of Pluto (Buie 1992,Young 1994, Sicardy 2005),
which makes it larger relative to its primary than any other moon in the Solar
System. Previous searches for other satellites around Pluto have been
unsuccessful (Stern 1991, Stern 1994, Stern 2003), but they were not sensitive
to objects <=150 km in diameter and there are no fundamental reasons why Pluto
should not have more satellites (Stern 1994). Here we report the discovery of
two additional moons around Pluto, provisionally designated S/2005 P1
(hereafter P1) and S/2005 P2 (hereafter P2), which makes Pluto the first Kuiper
belt object (KBO) known to have multiple satellites. These new satellites are
much smaller than Charon (diameter~1200 km), with P1 ranging in diameter from
60-165 km depending on the surface reflectivity, and P2 about 20% smaller than
P1. Although definitive orbits cannot be derived, both new satellites appear to
be moving in circular orbits in the same orbital plane as Charon, with orbital
periods of ~38 days (P1) and ~25 days (P2). The implications of the discovery
of P1 and P2 for the origin and evolution of the Pluto system, and for the
satellite formation process in the Kuiper belt, are discussed in a companion
paper (Stern 2006).Comment: Preprint of a paper accepted for publication in the journal Natur
Inflation and dark matter in two Higgs doublet models
We consider the Higgs inflation in the extension of the Standard Model with
two Higgs doublets coupled to gravity non-minimally. In the presence of an
approximate global U(1) symmetry in the Higgs sector, both radial and angular
modes of neutral Higgs bosons drive inflation where large non-Gaussianity is
possible from appropriate initial conditions on the angular mode. We also
discuss the case with single-field inflation for which the U(1) symmetry is
broken to a Z_2 subgroup. We show that inflationary constraints, perturbativity
and stability conditions restrict the parameter space of the Higgs quartic
couplings at low energy in both multi- and single-field cases. Focusing on the
inert doublet models where Z_2 symmetry remains unbroken at low energy, we show
that the extra neutral Higgs boson can be a dark matter candidate consistent
with the inflationary constraints. The doublet dark matter is always heavy in
multi-field inflation while it can be light due to the suppression of the
co-annihilation in single-field inflation. The implication of the extra quartic
couplings on the vacuum stability bound is also discussed in the light of the
recent LHC limits on the Higgs mass.Comment: (v1) 28 pages, 8 figures; (v2) 29 pages, a new subsection 3.3 added,
references added and typos corrected, to appear in Journal of High Energy
Physic
- âŠ